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    PDGFR2 & VEGFR2

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    Anti-PDGFR2 & VEGFR2 Products

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    For Research Use Only. Not For Clinical Use.


    Background

    VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) is a key receptor tyrosine kinase that plays a crucial role in angiogenesis (the formation of new blood vessels) and endothelial cell function. It binds to Vascular Endothelial Growth Factor (VEGF), which then triggers signaling pathways that regulate blood vessel formation, endothelial cell survival, proliferation, and migration. Because of its role in tumor growth, VEGFR2 is a significant target for cancer therapies, specifically VEGFR2 tyrosine kinase inhibitors, which block its signaling to inhibit tumor angiogenesis.
    This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
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