Anti-CD98 (clone IGNX)-DBM-MMAF ADC (CAT#: ADC-106LZY)

• Antibody Overview
• IGNX (Anti-Human CD98 mAb)

• Clone
• IGNX

• Antibody Conjugation
• cysteine cross-linking.

• Linker
• DBM(dibromomaleimide)

• Drug
• MMAF(monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

• Alternative Names
• SLC3A2; solute carrier family 3 (amino acid transporter heavy chain), member 2; 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; 4F2 cell-surface antigen heavy chain; CD98 heavy chain; monoclonal antibody 44D7; solute carrier family 3 member 2; lymphocyte activation antigen 4F2 large subunit; antigen defined by monoclonal antibody 4F2, heavy chain; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2;

• Gene ID
• 6520

• UniProt ID
• J3KPF3

• ADC-108LZY
• Anti-CD98 (clone IGNX)-mc-MMAF ADC

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