Anti-CD98 (clone IGNX)-mc-MMAF ADC
CAT#: ADC-108LZY
This ADC product is composed of an anti-CD98 antibody (clone IGNX) conjugated via mc linker to MMAF (IGNX-mc-MMAF). It has demonstrated a response in lung carcinoma, ovarian tumor treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17980/117_E9_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17980/44152_B_9_5.jpg
Normal Tissue
Figure 3 Pancreas
Pancreatic endocrine cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17980/44152_A_3_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17980/44152_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17980/44152_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (hTCEpi, SiHa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168003-SLC3A2
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Specifications
- Antibody Overview
- IGNX(Anti-Human CD98 mAb)
- Clone
- IGNX
- Linker
- mc(maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- MMAF(monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
- Alternative Names
- SLC3A2; solute carrier family 3 (amino acid transporter heavy chain), member 2; 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; 4F2 cell-surface antigen heavy chain; CD98 heavy chain; monoclonal antibody 44D7; solute carrier family 3 member 2; lymphocyte activation antigen 4F2 large subunit; antigen defined by monoclonal antibody 4F2, heavy chain; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2;
- Gene ID
- 6520
- UniProt ID
- J3KPF3
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Datasheet
MSDS
COA
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