Kunitz domains scaffold protein anti-Human Neutrophil elastase
CAT#: SKD-L101
The Kunitz domain that bound Neutrophil elastase was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=50 pM) for Neutrophil elastase as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
Hematopoietic cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73774/170937_B_6_4.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
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Specifications
- Scaffold Name
- Kunitz domains
- Origin
- BPTI
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 1–2 Loops
- Target
- Neutrophil elastase
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3)
- Affinity Constant
- 50 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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|---|---|---|---|
| DrMAB-1041 | Mouse Anti-ELANE Recombinant Antibody (clone YC039); Fab Fragment | ELISA | Mouse Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1136 | Hi-Affi™ Rabbit Anti-ELANE Recombinant Antibody (clone DS1136AB) | WB, IHC, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| VS-0325-XY760 | Anti-ELANE Immunohistochemistry Kit | IHC | |
| VS-0525-XY2241 | Anti-Human ELANE Immunohistochemistry Kit | IHC | |
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