Kunitz domains scaffold protein anti-Human Neutrophil elastase (CAT#: SKD-L101)
The Kunitz domain that bound Neutrophil elastase was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=50 pM) for Neutrophil elastase as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Bone marrow
(Hematopoietic cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73774/170937_B_6_4.jpg
(Hematopoietic cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73774/170937_B_6_4.jpg
Figure 2 RNA cell line category: Cell line enriched (THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
Figure 2 RNA cell line category: Cell line enriched (THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197561-ELANE
Specifications
- Scaffold Name
- Kunitz domains
- Origin
- BPTI
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 1–2 Loops
- Target
- Neutrophil elastase
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3)
- Affinity Constant
- 50 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- BPTI; Kunitz domains; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E
- Gene ID
- 1991
- UniProt ID
- P08246
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1041 | Mouse Anti-ELANE Recombinant Antibody (clone YC039); Fab Fragment | ELISA | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
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