Kunitz domains scaffold protein anti-Human Plasmin (CAT#: SKD-L118)
The Kunitz domain that bound plasmin was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=87 pM) for plasmin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Specifications
- Scaffold Name
- Kunitz domains
- Origin
- LACI-D1
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 4, 5 or 9 aa
- Target
- Plasmin
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 87 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- LACI-D1; Kunitz domains; PLA; human plasmin; plasmin
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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