This immunotoxin was achieved by conjugating/fusing the MSH to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to melanomas cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of melanomas.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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MOB-2308z | Mouse Anti-MC1R Recombinant Antibody (clone 40A1) | WB, IHC | Mouse IgM |
CBPAB-037LC | Rabbit Anti-MC1R Polyclonal Antibody | WB | Rabbit IgG |
VS3-QX760 | Mouse Anti-MC1R Recombinant Antibody (clone 578CT6.2.3) | WB | Mouse IgM |
CAT | Product Name | Application | Type |
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NABL-006 | Recombinant Anti-human MC1R VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
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MOR-2185 | Hi-Affi™ Recombinant Rabbit Anti-MC1R Monoclonal Antibody (DS2185AB) | WB, IHC | IgG |
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