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    PE-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (CAT#: MHC-LC191)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of AIM2-derived peptide of RSDSGQQARY sequence and A*01:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
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    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/if_selected.jpg
    Figure 2 IF staining of human cell line RT4
    Figure 2 IF staining of human cell line RT4
    (Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/40309/1396_B8_4_selected.jpg
    Normal Tissue
    Figure 3 IHC staining of human small intestine
    Figure 3 IHC staining of human small intestine
    (Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/ihc_selected.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_9_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_7_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_7_5.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_4_6.jpg
    Figure 9 Lymph node
    Figure 9 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31365/67668_A_8_8.jpg
    RNA Expression
    Figure 10 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70, U-266/84, U-87 MG)
    Figure 10 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70, U-266/84, U-87 MG)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163568-AIM2

    Specifications

    • Allele
    • A*01:01
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • Antigen isolated from immunoselected melanoma-2 (AIM2)
    • Antigen Species
    • Human
    • Peptide
    • RSDSGQQARY
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
    • Alternative Names
    • AIM2; absent in melanoma 2

    Downloads

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    MHC-YF316 A*01:01/Human AIM-2 (RSDSGQQARY) MHC Pentamer FCM

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