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AIM2

Anti-AIM2 Products

PE-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (MHC-LC191)
- Class: Class I
- Antigen: Antigen isolated from immunoselected melanoma-2 (AIM2)
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: PE
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APC-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (MHC-LC192)
- Class: Class I
- Antigen: Antigen isolated from immunoselected melanoma-2 (AIM2)
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: APC
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A*01:01/Human AIM-2 (RSDSGQQARY) MHC Pentamer (MHC-YF316)
- Class: Class I
- Antigen: AIM-2
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: Unlabeled, Biotin, R-PE, APC
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Mouse Anti-AIM2 Recombinant Antibody (clone 4G-11) (VS3-QX26)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, FC
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Mouse Anti-AIM2 Recombinant Antibody (clone 3F12F3) (VS3-XY33)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
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Mouse Anti-AIM2 Recombinant Antibody (clone 2G1D5) (VS3-XY34)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
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Anti-AIM2 (clone W24V55) Recombinant Antibody Coupled Liposome (VS-1024-FY59) (VS-1024-FY59)
- Antibody Host: Mouse
- Antibody Reactivity: Human
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Anti-AIM2 Immunohistochemistry Kit (VS-0325-XY69)
- Species Reactivity: Human, Mouse, Rat
- Target: AIM2
- Application: IHC
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For Research Use Only. Not For Clinical Use.

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

Predicted location

Intracellular

Single cell type specificity

Group enriched (B-cells, Plasma cells, Late spermatids, Early spermatids)

Immune cell specificity

Group enriched (memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70, U-266/84, U-87 MG)

Interaction

Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform (PubMed:15582594, PubMed:19158676). Component of the AIM2 inflammasome (PubMed:22869553, PubMed:22483801). Interacts with PYCARD, IFI16, EIF2AK2/PKR and MAPRE1 (PubMed:19158676, PubMed:19158675, PubMed:19158679, PubMed:22046441, PubMed:22801494, PubMed:22869553). Interacts with PYDC5; disrupts assembly of the ALR inflammasome complex (PubMed:24531343). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (By similarity).

Molecular function

DNA-binding

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