Loading...
AIM2
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Predicted location
Intracellular
Single cell type specificity
Group enriched (B-cells, Plasma cells, Late spermatids, Early spermatids)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70, U-266/84, U-87 MG)
Interaction
Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform (PubMed:15582594, PubMed:19158676). Component of the AIM2 inflammasome (PubMed:22869553, PubMed:22483801). Interacts with PYCARD, IFI16, EIF2AK2/PKR and MAPRE1 (PubMed:19158676, PubMed:19158675, PubMed:19158679, PubMed:22046441, PubMed:22801494, PubMed:22869553). Interacts with PYDC5; disrupts assembly of the ALR inflammasome complex (PubMed:24531343). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (By similarity).
Molecular function
DNA-binding
More Types Infomation
- APC-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (MHC-LC192)
-
- Class: Class I
- Antigen: Antigen isolated from immunoselected melanoma-2 (AIM2)
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: APC
- PE-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (MHC-LC191)
-
- Class: Class I
- Antigen: Antigen isolated from immunoselected melanoma-2 (AIM2)
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: PE
- A*01:01/Human AIM-2 (RSDSGQQARY) MHC Pentamer (MHC-YF316)
-
- Class: Class I
- Antigen: AIM-2
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: Unlabeled, Biotin, R-PE, APC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, FC
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.