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    PE-A*01:01/Human GAS1 (GSDGGLDDY) MHC Tetramer (CAT#: MHC-LC4440)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human GAS1 of peptide GSDGGLDDY covering 256-264 and A*01:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HEK 293
    Figure 1 IF staining of human cell line HEK 293
    (Immunofluorescent staining of human cell line HEK 293 shows localization to nuclear speckles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/36085/765_G1_1_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human pancreas
    Figure 2 IHC staining of human pancreas
    (Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_2_3_selected.jpg
    Figure 3 Lymph node
    Figure 3 Lymph node
    (Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_7_8.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_B_7_5.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_8_5.jpg
    Figure 6 Urinary bladder
    Figure 6 Urinary bladder
    (Urothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_6_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_6_6.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, ASC diff, BJ hTERT+, HSkMC, RH-30)
    Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, ASC diff, BJ hTERT+, HSkMC, RH-30)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000180447-GAS1

    Specifications

    • Allele
    • A*01:01
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • GAS1
    • Antigen Species
    • Human
    • Peptide
    • GSDGGLDDY
    • Range
    • 256-264
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
    • Alternative Names
    • GAS1; Growth arrest-specific protein 1 precursor

    Downloads

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