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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    PE-A*02:01/Human HDAC1 (RMLPHAPGV) MHC Tetramer (CAT#: MHC-LC1937)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HDAC1 of peptide RMLPHAPGV covering 371-379 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

    Specific Inquiry
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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5017/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_7_3.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_7_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Hepatocytes
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Cells in tubules
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Preleptotene spermatocytes
    Staining: Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_6_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Non-germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_8_8.jpg
    Figure 8 Tonsil
    Figure 8 Tonsil
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Squamous epithelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68191/152052_A_6_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Low cell line specificity
    Figure 9 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000116478-HDAC1

    Specifications

    • Allele
    • A*02:01
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • HDAC1
    • Antigen Species
    • Human
    • Peptide
    • RMLPHAPGV
    • Range
    • 371-379
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
    • Alternative Names
    • HDAC1; Histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1

    Related Resources

    • Related Diseases

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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