PE-A*02:01/Human RRM1 (GLYSGVTTV) MHC Tetramer (CAT#: MHC-LC1925)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human RRM1 of peptide GLYSGVTTV covering 46-54 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
Figure 3 Tonsil.
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
Figure 4 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
Figure 6 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- RRM1
- Antigen Species
- Human
- Peptide
- GLYSGVTTV
- Range
- 46-54
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- Alternative Names
- RRM1; Ribonucleoside-diphosphate reductase M1 chain; R1; RR1; RIR1
- Gene ID
- 6240
- UniProt ID
- P23921
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|---|---|---|---|
| MOB-2841z | Mouse Anti-RRM1 Recombinant Antibody (clone 41D1) | WB, ICC, IF, IHC | Mouse IgG1 |
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| MRO-1349-CN | Recombinant Rabbit Anti-RRM1 Monoclonal Antibody (JB09-43) | WB, IHC, FC, IP | Rabbit IgG |
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| VS13-YC1020 | Rabbit Anti-RRM1 Recombinant Antibody (VS13-YC1020) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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