Anti-RRM1 Recombinant Antibody (VS3-FY2865) (CAT#: VS3-FY2865)
The anti-RRM1 is an impressive recombinant monoclonal antibody that specifically reacts with human RRM1 protein. It can be used in the disease research of Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 6 and Lung Cancer.
| Sub Cat | Host Animal | Applications | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2939 | Rabbit | Western Blot, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 Immunohistochemistry: 1/50-1/100 Immunocytochemistry: 1/50-1/200 |
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| VS3-FY2866 | Mouse | ELISA, Western Blot, Immunohistochemistry, Flow cytometry |
Western Blot: 1/500-1/2000 Immunohistochemistry: 1/50-1/200 Flow cytometry: 1/50-1/200 ELISA: 1/1000-1/10000 |
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
Figure 3 Tonsil.
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
Figure 4 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
Figure 6 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
Specifications
- Type
- IgG
- Specificity
- Human RRM1
- Species Reactivity
- Human
- Conjugate
- Unconjugated, FITC
- Related Disease
- Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 6 and Lung Cancer
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ribonucleotide Reductase Catalytic Subunit M1; Ribonucleoside-Diphosphate Reductase Subunit M1; Ribonucleotide Reductase M1 Polypeptide; EC 1.17.4.1; RR1; Ribonucleoside-Diphosphate Reductase Large Subunit
- Gene ID
- 6240
- UniProt ID
- P23921
- Sequence Similarities
- Belongs to the ribonucleoside diphosphate reductase large chain family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys24, Lys70, Lys92, Lys111, Lys128, Lys149, Lys158, Lys180, Lys243, Lys376, Lys414, Lys465, Lys471, Lys479, Lys496, Lys643, Lys656, Lys681, Lys689, Lys693, Lys719, Lys729, Lys733, and Lys754 (NX_P23921 [NX_P23921-1])
Modification sites at PhosphoSitePlus (P23921)
Glycosylation from GlyGen (P23921) 6 sites, 1 O-linked glycan (6 sites)
- Protein Refseq
- NP_001304993.1; NP_001304994.1; NP_001317122.1
- Function
- Provides the precursors necessary for DNA synthesis.
Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2841z | Mouse Anti-RRM1 Recombinant Antibody (clone 41D1) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0822MZ | Recombinant Mouse Anti-Human RRM1 Antibody | WB | Mouse antibody |
| MRO-1349-CN | Recombinant Rabbit Anti-RRM1 Monoclonal Antibody (JB09-43) | WB, IHC, FC, IP | Rabbit IgG |
| ZG-0194U | Mouse Anti-RRM1 Recombinant Antibody (clone 3D6H5) | ELISA, IHC | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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