Anti-RRM1 Recombinant Antibody (VS3-FY2865)
CAT#: VS3-FY2865
The anti-RRM1 is an impressive recombinant monoclonal antibody that specifically reacts with human RRM1 protein. It can be used in the disease research of Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 6 and Lung Cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
Normal Tissue
Figure 3 Tonsil.
High expression in tonsil
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
❮
❯
| Sub Cat | Host Animal | Applications | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2939 | Rabbit | Western Blot, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 Immunohistochemistry: 1/50-1/100 Immunocytochemistry: 1/50-1/200 |
||||||
| VS3-FY2866 | Mouse | ELISA, Western Blot, Immunohistochemistry, Flow cytometry |
Western Blot: 1/500-1/2000 Immunohistochemistry: 1/50-1/200 Flow cytometry: 1/50-1/200 ELISA: 1/1000-1/10000 |
Specifications
- Type
- IgG
- Specificity
- Human RRM1
- Species Reactivity
- Human
- Conjugate
- Unconjugated, FITC
- Related Disease
- Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 6 and Lung Cancer
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ribonucleotide Reductase Catalytic Subunit M1; Ribonucleoside-Diphosphate Reductase Subunit M1; Ribonucleotide Reductase M1 Polypeptide; EC 1.17.4.1; RR1; Ribonucleoside-Diphosphate Reductase Large Subunit
- Gene ID
- 6240
- UniProt ID
- P23921
- Sequence Similarities
- Belongs to the ribonucleoside diphosphate reductase large chain family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys24, Lys70, Lys92, Lys111, Lys128, Lys149, Lys158, Lys180, Lys243, Lys376, Lys414, Lys465, Lys471, Lys479, Lys496, Lys643, Lys656, Lys681, Lys689, Lys693, Lys719, Lys729, Lys733, and Lys754 (NX_P23921 [NX_P23921-1])
Modification sites at PhosphoSitePlus (P23921)
Glycosylation from GlyGen (P23921) 6 sites, 1 O-linked glycan (6 sites)
- Protein Refseq
- NP_001304993.1; NP_001304994.1; NP_001317122.1
- Function
- Provides the precursors necessary for DNA synthesis.
Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "RRM1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0822MZ | Recombinant Mouse Anti-Human RRM1 Antibody | WB | Mouse antibody |
| MRO-1349-CN | Recombinant Rabbit Anti-RRM1 Monoclonal Antibody (JB09-43) | WB, IHC, FC, IP | Rabbit IgG |
| VS13-YC1020 | Rabbit Anti-RRM1 Recombinant Antibody (VS13-YC1020) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR796 | Mouse Anti-RRM1 Recombinant Antibody (clone 2D6D8) | WB, IHC, FC | Mouse IgG2a |
| VS7-0425-WR797 | Mouse Anti-RRM1 Recombinant Antibody (clone 5F12E6) | WB, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3131 | Hi-Affi™ Recombinant Rabbit Anti-RRM1 Monoclonal Antibody (DS3131AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1925 | PE-A*02:01/Human RRM1 (GLYSGVTTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1972 | Anti-RRM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6243 | Anti-Mouse RRM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6242 | Anti-Human RRM1 Immunohistochemistry Kit | IHC |
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