PE-A*02:02/Human PSMA1 (SLIGSKTQI) MHC Tetramer
CAT#: MHC-LC4286
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PSMA1 of peptide SLIGSKTQI covering 110-118 and A*02:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37646/if_selected.jpg
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Specifications
- Allele
- A*02:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- PSMA1
- Antigen Species
- Human
- Peptide
- SLIGSKTQI
- Range
- 110-118
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
- Alternative Names
- PSMA1; Proteasome subunit alpha type-1; NU; HC2; PROS30; HEL-S-275
- Gene ID
- 5682
- UniProt ID
- P25786
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