PE-A*31:01/Human CHRM1 (RYFSVTRPL) MHC Tetramer (CAT#: MHC-LC4353)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CHRM1 of peptide RYFSVTRPL covering 123-131 and A*31:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_B_8_5.jpg
Figure 2 Cerebellum
(G L U C cells - cytoplasm/membrane Staining: Medium Intensity: Moderate G L U Molecular layer cells - cytoplasm/membrane Staining: High Intensity: Strong Processes in molecular layer Staining: Medium Intensity: Moderate Purkinje cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Purkinje cells - dendrites Staining: Low Intensity: Weak White matter cells - cytoplasm/membrane Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_B_8_8.jpg
(G L U C cells - cytoplasm/membrane Staining: Medium Intensity: Moderate G L U Molecular layer cells - cytoplasm/membrane Staining: High Intensity: Strong Processes in molecular layer Staining: Medium Intensity: Moderate Purkinje cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Purkinje cells - dendrites Staining: Low Intensity: Weak White matter cells - cytoplasm/membrane Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_B_8_8.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_A_8_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_A_8_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_A_4_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14101/151888_A_4_6.jpg
Figure 5 RNA cell line category: Group enriched (MCF7, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168539-CHRM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168539-CHRM1
Specifications
- Allele
- A*31:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- CHRM1
- Antigen Species
- Human
- Peptide
- RYFSVTRPL
- Range
- 123-131
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
- Alternative Names
- CHRM1; Muscarinic acetylcholine receptor M1; M1; HM1; M1R
- Gene ID
- 1128
- UniProt ID
- P11229
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2014z | Mouse Anti-CHRM1 Recombinant Antibody (clone 36C10) | WB, ELISA, IF, IP | Mouse IgG2a, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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