PE-B*07:02/Human HLA-DPB1 (APRTVALTA) MHC Tetramer (CAT#: MHC-LC4377)

• Allele
• B*07:02

• Class
• Class I

• MHC Species
• Human

• Antigen
• HLA-DPB1

• Antigen Species
• Human

• Peptide
• APRTVALTA

• Range
• 9-17

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

• Alternative Names
• HLA-DPB1; HLA class II histocompatibility antigen, DP; DPB1; HLA-DP; HLA-DPB; HLA-DP1B

• Gene ID
• 3115

• UniProt ID
• P04440

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