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HLA-DPB1
Anti-HLA-DPB1 Recombinant Antibody Products
- PE-B7/Human HLA-DPB1 (APRTVALTA) MHC Tetramer (MHC-LC1969)
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- Class: Class I
- Antigen: HLA-DPB1
- Antigen Species: Human
- Peptide: APRTVALTA
- Conjugate: PE
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- PE-B*07:02/Human HLA-DPB1 (APRTVALTA) MHC Tetramer (MHC-LC4377)
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- Class: Class I
- Antigen: HLA-DPB1
- Antigen Species: Human
- Peptide: APRTVALTA
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Protein class
Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Langerhans cells, monocytes, Macrophages, Kupffer cells, B-cells)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Group enriched (HDLM-2, REH)
Interaction
Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
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