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    PE-B*07:02/Human MEF2D (RPASAGAML) MHC Tetramer (CAT#: MHC-LC4448)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human MEF2D of peptide RPASAGAML covering 198-206 and B*07:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4807/if_selected.jpg
    Normal Tissue
    Figure 2 Skeletal muscle
    Figure 2 Skeletal muscle
    (High expression in skeletal muscle)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4807/13926_B_2_6_val_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7114/18811_B_8_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7114/18626_A_7_3.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Spermatogonia cells Staining: Medium Intensity: Moderate)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7114/18626_A_6_6.jpg
    Figure 6 Placenta
    Figure 6 Placenta
    (Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7114/18626_A_1_7.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7114/18626_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (THP-1, U-266/70, U-266/84)
    Figure 8 RNA cell line category: Cell line enhanced (THP-1, U-266/70, U-266/84)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000116604-MEF2D

    Specifications

    • Allele
    • B*07:02
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • MEF2D
    • Antigen Species
    • Human
    • Peptide
    • RPASAGAML
    • Range
    • 198-206
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
    • Alternative Names
    • MEF2D; Myocyte-specific enhancer factor 2D

    Downloads

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