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MEF2D
Loading...Anti-MEF2D Products
- Recombinant Mouse Anti-Human MEF2D Antibody (MOB-1423MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- PE-B*07:02/Human MEF2D (RPASAGAML) MHC Tetramer (MHC-LC4448)
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- Class: Class I
- Antigen: MEF2D
- Antigen Species: Human
- Peptide: RPASAGAML
- Conjugate: PE
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- AbPlus™ Anti-MEF2D Magnetic Beads (VS-0724-YC81) (VS-0724-YC81)
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- Target: MEF2D
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-MEF2D Immunohistochemistry Kit (VS-0325-XY1330)
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- Species Reactivity: Human, Mouse, Rat
- Target: MEF2D
- Application: IHC
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- Anti-Mouse MEF2D Immunohistochemistry Kit (VS-0525-XY4345)
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- Species Reactivity: Human, Mouse, Rat
- Target: MEF2D
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (THP-1, U-266/70, U-266/84)
Interaction
Interacts with MYOG (By similarity). Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A. Interacts with MAPK7; the interaction phosphorylates but does not activate MEF2D (By similarity). Interacts with CCAR2 and HDAC3.
Molecular function
Activator, Developmental protein, DNA-binding
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