APC-B*07:02/Human POLR2A (TPQSNRPVM) MHC Tetramer

CAT#: MHC-LC2085

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human POLR2A of peptide TPQSNRPVM covering 527-535 and B*07:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Specifications

  • Allele
  • B*07:02
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • POLR2A
  • Antigen Species
  • Human
  • Peptide
  • TPQSNRPVM
  • Range
  • 527-535
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • POLR2A; DNA-directed RNA polymerase II subunit RPB1; RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220
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