PE-DRB1*13:01/Human HLA-DQB1 (TERVRLVTRHIYNRE) MHC Tetramer
CAT#: MHC-LC3357
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-DQB1 of peptide TERVRLVTRHIYNRE covering 13-27 and DRB1*13:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line HEK 293 shows localization to rods & rings.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/1729_E2_3_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31953_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31340_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31340_A_9_5.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31340_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000179344-HLA-DQB1
❮
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Specifications
- Allele
- DRB1*13:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- HLA-DQB1
- Antigen Species
- Human
- Peptide
- TERVRLVTRHIYNRE
- Range
- 13-27
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
- Alternative Names
- HLA-DQB1; HLA-DQB1 protein; IDDM1; CELIAC1; HLA-DQB
- Gene ID
- 3119
- UniProt ID
- O78046
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Datasheet
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COA
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