Recombinant Anti-Cyanobacteria MC-LR Antibody (CAT#: MOB-647)
Recombinant Mouse Antibody recognises an antigen Cyanobacteria MC-LR, expressed in Chinese Hamster Ovary cells(CHO).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- Microcystin-LR
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native Microcystin-LR
- Applications
- Products can be used for: Enzyme-linked Immunosorbent Assay; Western blot; Immunoprecipitation; Functional Study
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- Microcystin-LR; MC-LR
Related Resources
Wang, Jie, et al. "Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206+ M2-like macrophage polarization." Cell death & disease 11.2 (2020): 136. https://doi.org/10.1038/s41419-020-2329-z
This research investigates the therapeutic potential of microcystin-LR, an environmental cyanobacterial toxin, in treating idiopathic pulmonary fibrosis (IPF). The study demonstrates that chronic oral administration of microcystin-LR attenuates pulmonary fibrosis in both bleomycin-induced rat and fluorescein isothiocyanate-induced mouse models. Mechanistically, microcystin-LR reduces TGF-β1/Smad signaling in pulmonary tissues and blocks epithelial-mesenchymal transition (EMT) and fibroblast-myofibroblast transition (FMT) by suppressing the differentiation of CD206+ M2-like macrophages. Further investigation revealed that microcystin-LR binds to glucose-regulated protein 78 kDa (GRP78) and suppresses endoplasmic reticulum unfolded protein response (UPRER) signaling pathways, which modulates M2 polarization of macrophages and contributes to the alleviation of pulmonary fibrosis.
Creative Biolabs provided two independent microcystin-LR antibodies (CAT#: MOB-647) that were crucial for the immunoprecipitation and protein mass spectrometry experiments identifying GRP78 as the binding partner of microcystin-LR. This finding was central to revealing the novel mechanism through which microcystin-LR exerts its anti-fibrotic effects by modulating ER stress and M2 macrophage polarization, opening potential new therapeutic approaches for treating IPF, a condition with currently limited treatment options.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-647-F(E) | Recombinant Anti-Cyanobacteria MC-LR Antibody Fab Fragment | WB, IF, FuncS | Fab |
| MHH-647-F(E) | Recombinant Human Anti-Cyanobacteria MC-LR Antibody Fab Fragment | FC, RIA, Biosensors, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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