Recombinant Human Anti-human NBN Antibody (CAT#: MHH-692)
Recombinant Human Antibody is bind to Human NBN, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-NBN mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-NBN mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/if_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong nuclear positivity in cells of seminiferous ducts and Leydig cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_4_6_selected.jpg
(Immunohistochemical staining of human testis shows strong nuclear positivity in cells of seminiferous ducts and Leydig cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_4_6_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4996_B_9_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4996_B_9_5.jpg
Figure 4 Colon
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_9_3.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_9_3.jpg
Figure 5 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_9_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_9_4.jpg
Figure 6 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_7_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_7_5.jpg
Figure 7 Cervix
(Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4996_B_7_3.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4996_B_7_3.jpg
Figure 8 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1429/4888_A_7_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104320-NBN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104320-NBN
Specifications
- Immunogen
- Human nibrin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human nibrin
- Species Reactivity
- Human
- Applications
- Products can be used for: Flow Cytometry; Western blot; Functional Study
Product Property
- Purity
- >95% by HPLC
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- NBN; nibrin; ATV; NBS; P95; NBS1; AT-V1; AT-V2; Nijmegen breakage syndrome 1 (nibrin); cell cycle regulatory protein p95; p95 protein of the MRE11/RAD50 complex
- Gene ID
- 4683
- UniProt ID
- O60934
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-692-F(E) | Recombinant Anti-human NBN Antibody Fab Fragment | IP, RIA, FuncS | Fab |
| MHH-692-F(E) | Recombinant Human Anti-human NBN Antibody Fab Fragment | IF, FC, FuncS | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-692-S(P) | Recombinant Anti-human NBN Antibody scFv Fragment | WB, IF, FuncS | scFv |
| MHH-692-S(P) | Recombinant Human Anti-human NBN Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1879MZ | Recombinant Mouse Anti-Human NBN Antibody (clone 2E8) | IP, WB | Mouse antibody |
| MRO-2354-CN | Recombinant Rabbit Anti-NBN (phosphorylated Ser343) Monoclonal Antibody (CBACN-643) | WB, IF, IHC, IP | Rabbit IgG |
| ZG-0481U | Rabbit Anti-Phospho-NBN (S343) Recombinant Antibody (clone 1B4) | ELISA, WB | Rabbit IgG |
| VS3-XY1135 | Mouse Anti-NBN Recombinant Antibody (clone 7E4A2) | ELISA, WB, IHC, FC, ICC | Mouse IgG2a |
| VS3-XY1136 | Mouse Anti-NBN Recombinant Antibody (clone 7E4C2) | ELISA, WB, IHC, FC, ICC | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2371 | Hi-Affi™ Recombinant Rabbit Anti-NBN Monoclonal Antibody (DS2371AB) | ICC, IP, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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