This Factor VIII specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=5 nM) for Factor VIII as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1409z | Mouse Anti-F7 Recombinant Antibody (clone 36D2) | ELISA, WB | Mouse IgG1 |
MOB-0375MZ | Recombinant Mouse Anti-Human Factor VII Antibody (clone BIWIII-5032) | RIA, WB, ELISA | Mouse antibody |
MOB-1612MZ | Recombinant Mouse Anti-Human F7 Antibody | ELISA, RIA, WB | Mouse antibody |
FAMAB-1094CQ | Human Anti-F7 Recombinant Antibody (clone RFF-VII/1) | RIA, Block | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1228 | Hi-Affi™ Rabbit Anti-F7 Recombinant Antibody (clone DS1228AB) | WB | Rabbit IgG |
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