Anti-F7 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your source for research-grade, high-affinity anti-F7 recombinant antibodies. Coagulation Factor VII (F7) is an enzyme and the key initiator of the extrinsic pathway and hemostasis. With our recombinant anti-F7 antibodies (rAbs), researchers can explore this critical aspect of coagulation initiation, while the quality control and characterization of recombinant Factor VIIa (rFVIIa), a top-selling biotherapeutic for hemophilia and other severe bleeding disorders is more accurate than ever.

F7: The Initiator of Blood Coagulation

Coagulation Factor VII (F7) is a vitamin K-dependent, plasma glycoprotein serine protease that is synthesized in the liver. F7 is the primary initiator of the extrinsic (tissue factor) pathway of coagulation. The interaction of F7 with its transmembrane receptor Tissue Factor (TF) upon blood vessel injury is a key early event in coagulation. In the intact vasculature, TF is expressed on subendothelial cells and shielded from F7. F7 binding to and activation by TF lead to a TF/F7a complex that activates Factor X and Factor IX, thereby initiating the coagulation cascade that ultimately leads to clot formation. Inherited deficiency of F7 is an autosomal recessive disorder that can lead to a severe bleeding phenotype.

Alternative Names

SPCA

Background

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Anti-F7 rAb Products

Creative Biolabs’ recombinant anti-F7 antibodies are engineered for optimal binding affinity and reliable performance. The antibodies are fully validated for accurate detection of Factor VII in plasma and use in the characterization of biotherapeutics. Customized for multiple applications, including ELISA for quantification, Western Blot, and binding assays (i.e., SPR) for determination of F7-Tissue Factor binding, our recombinant antibodies (rAbs) are the best-in-class tools for hematology research.

Table 1. Featured anti-F7 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is leveraging state-of-the-art production technologies to make researchers’ work as fast and successful as possible. Our anti-F7 recombinant antibodies are developed with the utmost care to ensure the highest possible affinity and specificity for this important enzyme, making them ideal for sensitive analytical applications.

Featured Anti-F7 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-F7 recombinant antibody production.

Fig.2 Gram-scale anti-F7 recombinant antibody production.

rAb Modalities

Creative Biolabs believes in a flexible approach to your research needs. In addition to our fully validated matched pair for ELISA, our anti-F7 antibodies are available in a range of formats to support your research, diagnostics, or pharmaceutical quality control and research.

Fig.3 Full-length anti-F7 recombinant antibody production and modalities.

Speed up your biotherapeutic and hematology research with Creative Biolabs’ unmatched anti-F7 recombinant antibodies. From our portfolio you can source the high affinity and rigorous validation needed for sensitive analytical assays and the study of the initiation of coagulation. Choose us for quality that makes a difference. Contact our experts today.