APC-A*24:02/CMV IE1 (AYAQKIFKI) MHC Tetramer
CAT#: MHC-CN0522
Specifications
- Allele
- A*24:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- CMV IE1
- Antigen Species
- CMV
- Peptide
- AYAQKIFKI
- Conjugate
- APC
- Application
- FCM, IHC
Target
- Antigen Introduction
- Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. It is also known as human herpesvirus-5 (HHV-5). The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency. Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important. Both proteins have long been recognized as promiscuous transcriptional regulators.
- Alternative Names
- UL122
- Gene ID
- 3077563
- UniProt ID
- Q6SW29
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Excellent CMV IE1 Detection
We used this APC-conjugated tetramer to detect human CD8 T cells specific for the CMV IE1 peptide AYAQKIFKI. The A*24:02 restriction worked as expected, and we obtained clear populations in our flow cytometry analysis.
Robust Reagent for Viral Studies
This tetramer has been a key tool in our research on Cytomegalovirus. It reliably identifies T cells targeting the immediate-early protein, and the signal quality has been excellent for analyzing individual antigen-specific cells.
Q&As
-
Which CMV protein is targeted by this tetramer?
A: This tetramer targets the CMV Immediate-Early 1 (IE1) protein. It is loaded with the peptide sequence AYAQKIFKI and is presented by the HLA-A*24:02 molecule.
-
What is the conjugate on this MHC tetramer?
A: This product is conjugated with Allophycocyanin (APC). It is designed for use in flow cytometry (FCM) to detect human CD8 T cells specific for the CMV IE1 antigen.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
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COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CMV IE1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1536CQ | Recombinant Mouse Anti-CMV IE1 Antibody (MRO-1536CQ) | WB, IF | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1537CQ | Recombinant Mouse Anti-CMV IE1 Antibody (CH443) | IF, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC235 | BV421-B*08:01/CMV IE1 (ELRRKMMYM) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC272 | PE-B*08:01/CMV IE1 (QIKVRVDMV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC273 | APC-B*08:01/CMV IE1 (QIKVRVDMV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC274 | BV421-B*08:01/CMV IE1 (QIKVRVDMV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC364 | PE-B*08:01/CMV IE1 (ELRRKMMYM) MHC Tetramer | FCM |
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