Mouse Anti-ADIPOR1 Recombinant Antibody (clone FY072401) (CAT#: VS-0724-FY9)
This is a human monoclonal antibody that binds to human AdipoR1. Human AdipoR1 and AdipoR2 belong to the progesterone and adipoQ receptor families and are receptors for the anti-diabetic adipokine adiponectin. AdipoR1 activates the AMP-activated protein kinase (AMPK) pathway, while AdipoR2 activates the peroxisome proliferator-activated receptor-α (PPAR-α) pathway, leading to increased expression of uncoupling protein 2 (UCP2).
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RNA Expression
Figure 1 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000159346-ADIPOR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000159346-ADIPOR1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human AdipoR1
- Species Reactivity
- Human
- Clone
- FY072401
- Applications
- Immunoassay
- Related Disease
- Gestational Diabetes and Anorexia Nervosa
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Adiponectin Receptor 1; Progestin And AdipoQ Receptor Family Member 1; Progestin And AdipoQ Receptor Family Member I; TESBP1A; PAQR1; Adiponectin Receptor Protein 1; ACDCR1; CGI-45; CGI45
- Gene ID
- 51094
- UniProt ID
- Q96A54
- Long Name
- Adiponectin Receptor 1
- Sequence Similarities
- Belongs to the ADIPOR family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
- Post Translation Modifications
- Ubiquitination at Lys86
Modification sites at PhosphoSitePlus
- Protein Refseq
- XP_024303195.1; XP_047277915.1; XP_054192855.1; NP_001277482.1; NP_001277486.1
- Function
- Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism.
Required for normal glucose and fat homeostasis and for maintaining a normal body weight.
ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0085 | Hi-Affi™ Rabbit Anti-ADIPOR1 Recombinant Antibody (clone DS85AB) | WB, IHC, ICC, FC | Rabbit IgG |
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