Mouse Anti-AFG3L2 Recombinant Antibody (clone 2D3)
CAT#: VS-0625-FY14
This Mouse IgG1 monoclonal antibody, clone 2D3, is designed for detecting human AFG3L2. Its immunogen is a recombinant human AFG3L2 protein fragment, with an epitope spanning amino acids 1-250. With an approximate antigen size of 47.7 kDa, this antibody is validated for Western Blot at a dilution of 1:500, providing reliable detection for AFG3L2.
Specifications
- Immunogen
- A recombinant human AFG3L2 protein fragment (NP_006787, amino acids 1-250) expressed in E. coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Species Reactivity
- Human
- Clone
- 2D3
- Applications
- Western Blot
- Related Disease
- Spastic Paraplegia 55 (SPG55), Spinocerebellar Ataxia type 28 (SCA28).
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS pH 7.3, 1% BSA, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500
Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- AFG3 Like Matrix AAA Peptidase Subunit 2; Paraplegin-Like Protein; AFG3 Like AAA ATPase 2; AFG3 ATPase Family Member 3-Like 2 (S. cerevisiae); AFG3 (ATPase Family Gene 3, Yeast)-Like 2; AFG3 ATPase Family Member 3-Like 2; AFG3 ATPase Family Gene 3-Like 2; ATPase Family Gene 3, Yeast
- Gene ID
- 10939
- UniProt ID
- Q9Y4W6
- Long Name
- AFG3 Like Matrix AAA Peptidase Subunit 2
- Sequence Similarities
- In the N-terminal section; belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
- Cellular Localization
- Mitochondrion inner membrane
- Post Translation Modifications
- Upon import into the mitochondrion, the N-terminal transit peptide is cleaved to generate an intermediate form which undergoes autocatalytic proteolytic processing to generate the proteolytically active mature form.
- Protein Refseq
- XP_011523903.1; XP_054174138.1; NP_006787.2
- Function
- Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC859 | AbPlus™ Anti-AFG3L2 Magnetic Beads (VS-0724-YC859) | IP, Protein Purification |
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