Recombinant Anti-AFM Eliminating Antibody, pH-Sensitive (VS-0625-YC7)
CAT#: VS-0625-YC7
The anti-AFM eliminating antibody is an engineered pH-sensitive antibody against human AFM. AFM, part of the albumin gene family, is a serum protein secreted by the liver. The antibody has a novel AFM-sweeping activity in vivo, which selectively eliminatesthe soluble AFM from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 Kidney
Cells in tubules Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17006/147462_A_8_5.jpg
Normal Tissue
Figure 2 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Strong Quantity: <25% Round or early spermatids Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17006/147462_A_6_6.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17006/147462_B_7_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (CACO-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000079557-AFM
❮
❯
Specifications
- Immunogen
- Purified human afamin
- Host Species
- Mouse
- Type
- Mouse IgG1 kappa
- Specificity
- Human AFM
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0625-YC7. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "AFM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-442 | Mouse Anti-AFM Recombinant Antibody (PABC-442) | ELISA | Mouse IgG1, κ |
| VS-0923-FY5 | Recombinant Mouse Anti-AFM Antibody (VS-0923-FY5) | ELISA, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-442 | Mouse Anti-AFM Recombinant Antibody Fab Fragment (PFBC-442) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-442 | Mouse Anti-AFM Recombinant Antibody scFv Fragment (PSBC-442) | ELISA | Mouse scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, Inhib, FC, ELISA
Application: ELISA, FC
Application: WB, ELISA, FC, IHC, IF, IP
Application: ELISA, FuncS
-2.png)
Application: ELISA, WB
-2.png)
Application: ELISA
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
