Anti-AMACR (clone 4A12) Recombinant Antibody Coupled Liposome (VS-1024-FY295)
CAT#: VS-1024-FY295
Anti-AMACR antibody conjugated liposomes hold significant potential in prostate cancer research by enabling targeted delivery of therapeutic agents directly to cancer cells, thereby enhancing treatment efficacy while minimizing off-target effects. Additionally, their use as contrast agents in imaging studies could facilitate early detection and monitoring of disease progression, leading to improved patient outcomes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20912/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19527/48457_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19527/48457_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19527/48457_A_8_4.jpg
Normal Tissue
Figure 5 Pancreas
Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19527/48457_A_2_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19527/48457_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19527/48457_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000242110-AMACR
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- 4A12
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was meticulously designed to bind to AMACR, an enzyme involved in the metabolism of branched-chain fatty acids. The development of this antibody provides researchers with a powerful tool to investigate the function of AMACR in cancer biology and metabolic disorders. Its high specificity and affinity make it an essential reagent for studies aiming to elucidate the pathological roles of AMACR in various diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- AMACR
- Introduction
- This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
- Alternative Names
- Alpha-Methylacyl-CoA Racemase; 2-Methylacyl-CoA Racemase; EC 5.1.99.4; AMACRD; CBAS4; P504S; RACE; RM
- Full Name
- Alpha-Methylacyl-CoA Racemase
- Gene ID
- 23600
- UniProt ID
- Q9UHK6
- Sequence Similarities
- Belongs to the CoA-transferase III family.
- Cellular Localization
- Peroxisome; Mitochondrion
- Post Translation Modifications
- Ubiquitination at Lys135 ( NX_Q9UHK6 [NX_Q9UHK6-1] )
Modification sites at PhosphoSitePlus
- Protein Refseq
- NP_001161067.1; NP_055139.4; NP_976316.1
- Function
- Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone 4A12"
- CAT
- Product Name
See other products for "AMACR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0259MZ | Mouse Anti-AMACR Recombinant Antibody (clone 14I5) | IHC | Mouse IgG |
| MRO-0088-CN | Mouse Anti-AMACR Recombinant Antibody (clone 6F5) | WB, IHC, FC | Mouse IgG1 |
| ZG-0389U | Rabbit Anti-AMACR Recombinant Antibody (clone Q17-L) | IHC-P | Rabbit IgG |
| VS3-WK1193 | Mouse Anti-AMACR Recombinant Antibody (VS3-WK1193) | WB, IHC | Mouse IgG1 |
| VS3-WK1194 | Mouse Anti-AMACR Recombinant Antibody (clone PT1743) | IHC-P, WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0160 | Hi-Affi™ Rabbit Anti-AMACR Recombinant Antibody (clone DS160AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0570-YJ-S(P) | Mouse Anti-AMACR Recombinant Antibody (clone 4A12); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-0571-YJ-S(P) | Mouse Anti-AMACR Recombinant Antibody (clone ch4A12); scFv Fragment | ELISA, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0570-YJ-F(E) | Mouse Anti-AMACR Recombinant Antibody (clone 4A12); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-0571-YJ-F(E) | Human Anti-AMACR Recombinant Antibody (clone ch4A12); Fab Fragment | ELISA, IHC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY342 | Anti-AMACR Immunohistochemistry Kit | IHC | |
| VS-0525-XY343 | Anti-Mouse AMACR Immunohistochemistry Kit | IHC | |
| VS-0525-XY344 | Anti-Rat AMACR Immunohistochemistry Kit | IHC |
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