Recombinant Anti-APLN Eliminating Antibody, pH-Sensitive (VS-0625-YC20)
CAT#: VS-0625-YC20
The anti-APLN eliminating antibody is an engineered pH-sensitive antibody against human APLN. APLN peptide ligand regulates fluid homeostasis and cardiovascular functions via specific receptors. The antibody has a novel APLN-sweeping activity in vivo, which selectively eliminatesthe soluble APLN from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Specifications
- Immunogen
- Apelin peptide with KLH
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human APLN
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "APLN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-210-VHH | Recombinant Anti-Human APLN VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0928CLV | Mouse Anti-APLN Recombinant Antibody (TAB-0928CLV) | ELISA | Mouse IgG |
| TAB-0928CLV-F(E) | Mouse Anti-APLN Recombinant Antibody; Fab Fragment (TAB-0928CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0928CLV-S(P) | Mouse Anti-APLN Recombinant Antibody; scFv Fragment (TAB-0928CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0202 | Hi-Affi™ Rabbit Anti-APLN Recombinant Antibody (clone DS202AB) | ELISA | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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