Anti-APOBEC3B Antibody Prodrug, Protease Activated (VS-1025-YC173)
CAT#: VS-1025-YC173
The Anti-APOBEC3B Antibody Prodrug, Protease Activated (VS-1025-YC173) is an antibody prodrug comprised of a recombinant rabbit antibody targeting human APOBEC3B, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to APOBEC3B protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to APOBEC3B effectively. APOBEC3B is a DNA-editing enzyme whose overexpression in cancers is a major source of mutational signatures, driving tumor evolution and heterogeneity. Its aberrant activity generates C-to-T and C-to-G mutations, accelerating oncogenesis and potentially aiding drug resistance.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56980/956_H3_4_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (A-431, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000179750-APOBEC3B
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Specifications
- Host Animal
- Rabbit
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human APOBEC3B
- Target
- APOBEC3B
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- A3B; ARP4; ARCD3; PHRBNL; APOBEC1L; bK150C2.2; DJ742C19.2
- Gene ID
- 9582
- UniProt ID
- Q9UH17
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "APOBEC3B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043-LSX | Rabbit Anti-APOBEC3B Recombinant Antibody (HPAB-0043-LSX) | ELISA, IF, IB, IHC, DB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-169YJL | Rabbit Anti-APOBEC3B Recombinant Antibody (MOB-169YJL) | ELISA, WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-169YJL-S(P) | Rabbit Anti-APOBEC3B Recombinant Antibody; scFv Fragment (MOB-169YJL-S(P)) | ELISA, WB, IF | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-169YJL-F(E) | Rabbit Anti-APOBEC3B Recombinant Antibody; Fab Fragment (MOB-169YJL-F(E)) | ELISA, WB, IF | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1083 | AbPlus™ Anti-APOBEC3B Magnetic Beads (VS-0724-YC1083) | IP, Protein Purification |
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