Recombinant Anti-APOC3 Eliminating Antibody, pH-Sensitive (VS-0625-YC23)
CAT#: VS-0625-YC23
The anti-APOC3 eliminating antibody is an engineered pH-sensitive antibody against human and cynomolgus APOC3. APOC3 regulates triglyceride-rich lipoprotein metabolism, influencing cardiovascular disease risk. The antibody has a novel APOC3-sweeping activity in vivo, which selectively eliminatesthe soluble APOC3 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65365/1258_H7_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73918/168345_A_9_4_selected.jpg
Normal Tissue
Figure 3 Small intestine
Enterocytes Staining: Medium Intensity: Strong Quantity: <25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Goblet cells Staining: Medium Intensity: Strong Quantity: <25% Paneth cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73918/168345_A_4_2.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73918/168345_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73918/168345_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73918/168345_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (CACO-2, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110245-APOC3
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human and Cynomolgus APOC3
- Species Reactivity
- Human, Cynomolgus
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "APOC3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0952CLV-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (TAB-0952CLV-F(E)) | ELISA | Human Fab |
| TAB-0955CLV-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (TAB-0955CLV-F(E)) | ELISA | Human Fab |
| TAB-0956CLV-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (TAB-0956CLV-F(E)) | ELISA | Human Fab |
| TAB-0958CLV-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (TAB-0958CLV-F(E)) | ELISA | Human Fab |
| TAB-0960CLV-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (TAB-0960CLV-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0213 | Hi-Affi™ Rabbit Anti-APOC3 Recombinant Antibody (clone DS213AB) | FC, IP, WB | Rabbit IgG |
| MOR-4533 | Hi-Affi™ Rabbit Anti-APOC3 Recombinant Antibody (clone TH41DS) | WB, IF, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1655-CN | Rabbit Anti-APOC3 Polyclonal Antibody (MRO-1655-CN) | WB, IHC, FC | Rabbit IgG |
| HPAB-N0018-YC | Human Anti-APOC3 Recombinant Antibody (HPAB-N0018-YC) | ELISA, FuncS | Human IgG1 |
| HPAB-N0019-YC | Human Anti-APOC3 Recombinant Antibody (HPAB-N0019-YC) | ELISA | Human IgG1 |
| HPAB-N0020-YC | Human Anti-APOC3 Recombinant Antibody (HPAB-N0020-YC) | ELISA | Human IgG1 |
| VS3-XY3263 | Rabbit Anti-APOC3 Recombinant Antibody (clone R09-6C6) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0018-YC-S(P) | Human Anti-APOC3 Recombinant Antibody; scFv Fragment (HPAB-N0018-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-N0019-YC-S(P) | Human Anti-APOC3 Recombinant Antibody; scFv Fragment (HPAB-N0019-YC-S(P)) | ELISA | Human scFv |
| HPAB-N0020-YC-S(P) | Human Anti-APOC3 Recombinant Antibody; scFv Fragment (HPAB-N0020-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0018-YC-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (HPAB-N0018-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-N0019-YC-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (HPAB-N0019-YC-F(E)) | ELISA | Human Fab |
| HPAB-N0020-YC-F(E) | Human Anti-APOC3 Recombinant Antibody; Fab Fragment (HPAB-N0020-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY459 | Anti-APOC3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY460 | Anti-Mouse APOC3 Immunohistochemistry Kit | IHC |
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