Anti-BCL6 (clone GN15) Recombinant Antibody Coupled Liposome (VS-1024-FY164) (CAT#: VS-1024-FY164)

• Potential Clinical Applications
• Melanoma

• Clone
• GN15

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that was specifically designed to target BCL6, a protein that plays a crucial role in regulating immune responses and is implicated in various types of cancers, including diffuse large B-cell lymphoma. The antibody has been engineered to enhance its specificity and affinity for the BCL6 protein, allowing for precise identification and quantification of BCL6 expression in biological samples.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• BCL6

• Introduction
• The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

• Alternative Names
• B Cell CLL/Lymphoma 6; Zinc Finger Protein 51; Zinc Finger And BTB Domain-Containing Protein 27; B-Cell Lymphoma 5 Protein; Protein LAZ-3; ZBTB27; ZNF51; BCL-5; BCL-6; BCL5

• Full Name
• B Cell CLL/Lymphoma 6

• Gene ID
• 604

• UniProt ID
• P41182

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343.
  Phosphorylated by ATM in response to genotoxic stress.
  Phosphorylation induces its degradation by ubiquitin/proteasome pathway.

• Protein Refseq
• XP_005247751.1; XP_011511364.1; XP_047304611.1; XP_054203403.1; XP_054203404.1

• Function
• Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions.
  Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes.
  Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors.

• HPAB-1961-FY
• Human Anti-BCL6 Recombinant Antibody (clone GN15)

• HPAB-1961-FY-F(E)
• Human Anti-BCL6 Recombinant Antibody (clone GN15); Fab Fragment

• HPAB-1961-FY-S(P)
• Human Anti-BCL6 Recombinant Antibody (clone GN15); scFv Fragment

• HPAB-1961-FY-mRNA
• Human Anti-BCL6 Antibody (clone GN15), mRNA

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