Anti-BCL6 (clone GN15) Recombinant Antibody Coupled Liposome (VS-1024-FY164)
CAT#: VS-1024-FY164
BCL6 is often implicated in the regulation of apoptosis in melanoma cells, making it a valuable target for therapy. By using anti-BCL6 antibodies conjugated to liposomes, researchers aim to induce apoptosis selectively in melanoma cells while minimizing damage to healthy tissues. This method enhances the therapeutic index and could improve the outcomes of traditional chemotherapy or immunotherapy. Early studies indicate that this targeted approach may lead to a reduced tumor burden in melanoma models.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4899/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50645/1596_B12_4_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4899/1964_G1_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4899/1893_N4_3_cr5bbe00386e079_red_green.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/307/990_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HSkMC, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113916-BCL6
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- GN15
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was specifically designed to target BCL6, a protein that plays a crucial role in regulating immune responses and is implicated in various types of cancers, including diffuse large B-cell lymphoma. The antibody has been engineered to enhance its specificity and affinity for the BCL6 protein, allowing for precise identification and quantification of BCL6 expression in biological samples.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- BCL6
- Introduction
- The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
- Alternative Names
- B Cell CLL/Lymphoma 6; Zinc Finger Protein 51; Zinc Finger And BTB Domain-Containing Protein 27; B-Cell Lymphoma 5 Protein; Protein LAZ-3; ZBTB27; ZNF51; BCL-5; BCL-6; BCL5
- Full Name
- B Cell CLL/Lymphoma 6
- Gene ID
- 604
- UniProt ID
- P41182
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343.
Phosphorylated by ATM in response to genotoxic stress.
Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
- Protein Refseq
- XP_005247751.1; XP_011511364.1; XP_047304611.1; XP_054203403.1; XP_054203404.1
- Function
- Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions.
Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes.
Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors.
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Datasheet
MSDS
COA
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See other products for "Clone GN15"
- CAT
- Product Name
See other products for "BCL6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0263MZ | Mouse Anti-BCL6 Recombinant Antibody (clone QG-B7p) | IHC | Mouse IgG1 |
| HPAB-1961-FY | Human Anti-BCL6 Recombinant Antibody (clone GN15) | FC | Human IgG, λ |
| VS3-FY156 | Recombinant Mouse Anti-BCL6 Antibody (clone 7A6D1) | ELISA, WB, IHC, ICC, FC | Mouse IgG1 |
| VS7-HM218 | Mouse Anti-BCL6 Recombinant Antibody (clone 2G1B6) | ICC, FCM | Mouse IgG1 |
| VS13-YC99 | Rabbit Anti-BCL6 Recombinant Antibody (VS13-YC99) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0347 | Hi-Affi™ Rabbit Anti-BCL6 Recombinant Antibody (clone DS347AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1961-FY-F(E) | Human Anti-BCL6 Recombinant Antibody (clone GN15); Fab Fragment | FC | Human Fab, λ |
| HPAB-1962-FY-F(E) | Human Anti-BCL6 Recombinant Antibody (clone GN05); Fab Fragment | FC | Human Fab, κ |
| HPAB-1963-FY-F(E) | Human Anti-BCL6 Recombinant Antibody (clone GN14); Fab Fragment | FC | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1961-FY-S(P) | Human Anti-BCL6 Recombinant Antibody (clone GN15); scFv Fragment | FC | Human scFv |
| HPAB-1962-FY-S(P) | Human Anti-BCL6 Recombinant Antibody (clone GN05); scFv Fragment | FC | Human scFv |
| HPAB-1963-FY-S(P) | Human Anti-BCL6 Recombinant Antibody (clone GN14); scFv Fragment | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY4 | CytoStream™ Mouse Anti-BCL6 Recombinant Antibody (clone K112-91) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY742 | Anti-BCL6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY743 | Anti-Human BCL6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY744 | Anti-Mouse BCL6 Immunohistochemistry Kit | IHC |
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