Mouse Anti-Bet v 1 Recombinant Antibody (clone BV16) (CAT#: HPAB-S0006-YC)
BV16 is a murine IgG1 antibody raised by immunization with purified Bet v 1. BV16 partially inhibits the binding of human serum IgE to Bet v 1, the epitope defined by BV16 is partly or completely overlapping Bet v 1 epitopes recognized by human serum IgE originating from natural exposure.
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ELISA
Figure 1 Inhibition of IgE binding to surface-coated △29NCS_5x in the presence of both Bet v 1 and serial dilutions of Bet v 1-binding monoclonal mouse IgG antibody BV16 in ELISA.
In the absence of BV16, IgE binding to △29NCS_5x was inhibited to 84% by Bet v 1. The observed Bet v 1-induced inhibition of IgE-△29NCS_5x interaction could, however, been abolished by the monoclonal antibody BV16 in a dose-dependent manner. This result suggests a structural overlap between the individual cross-reactive IgE epitope of △29NCS_5x and the Bet v1-specific IgG epitope recognized by monoclonal antibody BV16.
Berkner, H., Seutter von Loetzen, C., Hartl, M., Randow, S., Gubesch, M., Vogel, L., ... & Schiller, D. (2014). Enlarging the toolbox for allergen epitope definition with an allergen-type model protein. PloS one, 9(10), e111691.
ELISA
Figure 2 Binding of serial dilutions of monoclonal BV16 to surface coated equimolar amounts of Bet v 1 and Bet v 1_4x in ELISA.
Interaction of monoclonal BV16 with Bet v 1_4x was virtually abolished.
Berkner, H., Seutter von Loetzen, C., Hartl, M., Randow, S., Gubesch, M., Vogel, L., ... & Schiller, D. (2014). Enlarging the toolbox for allergen epitope definition with an allergen-type model protein. PloS one, 9(10), e111691.
Specifications
- Immunogen
- Purified Bet v 1
- Host Species
- Mouse
- Type
- Mouse IgG1
- Species Reactivity
- Birch
- Clone
- BV16
- Applications
- ELISA, IB
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Birch pollen allergen Bet v1; Bet v1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1964-FY | Human Anti-Bet v 1 Recombinant Antibody (clone BAB2) | WB, ELISA | Human IgG |
| HPAB-1965-FY | Human Anti-Bet v 1 Recombinant Antibody (clone BAB3) | WB, ELISA | Human IgG |
| HPAB-1966-FY | Human Anti-Bet v 1 Recombinant Antibody (clone BAB4) | WB, ELISA | Human IgG |
| VS-0322-LC58 | Rabbit Anti-Bet v 1 Recombinant Antibody (clone BAB3) | WB, ELISA | |
| VS-0322-LC60 | Rabbit Anti-Bet v 1 Recombinant Antibody (clone M0418) | ELISA |
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