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  • Rabbit Anti-CDC73 Recombinant Antibody (clone R74-7K-3)

Rabbit Anti-CDC73 Recombinant Antibody (clone R74-7K-3) (CAT#: VS3-XY3304)

This is a recombinant rabbit antibody that specifically recognizes CDC73 (Cell division cycle 73), which involves in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. It also has cross-reactivity against mouse or rat CDC73. It has been reported for use in Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.


See more Engineered Antibody products for CDC73
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SiHa
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2326/1966_A9_2_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69324/1406_H8_6_selected.jpg
Figure 3 IHC staining of human colon
Figure 3 IHC staining of human colon
(Immunohistochemical staining of human colon shows nuclear positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/ihc_selected.jpg
Figure 4 IF staining of human cell line A-431
Figure 4 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/947_C11_1_red_green.jpg
Figure 5 IF staining of human cell line U-251 MG
Figure 5 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/952_C11_3_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Figure 6 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/36100_B_7_5.jpg
Figure 7 Adrenal gland
Figure 7 Adrenal gland
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/36100_B_6_5.jpg
Figure 8 Colon
Figure 8 Colon
(Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/36100_A_8_3.jpg
Figure 9 Kidney
Figure 9 Kidney
(Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/36100_A_8_5.jpg
Figure 10 Testis
Figure 10 Testis
(Round or early spermatids
Staining:High
Intensity: Strong
Quantity: 75%-25%
Spermatogonia cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/36100_A_5_6.jpg
Figure 11 Lymph node
Figure 11 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16359/36100_A_9_8.jpg
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Figure 12 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134371-CDC73

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat CDC73
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R74-7K-3
  • Applications
  • WB
  • Related Disease
  • Hyperparathyroidism 1 (HRPT1); Hyperparathyroidism 2 with jaw tumors (HRPT2); Parathyroid carcinoma (PRTC)

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000

Target

  • Alternative Names
  • HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28
  • Long Name
  • Cell division cycle 73
  • Cellular Localization
  • Nucleus
  • Post Translation Modifications
  • Phosphorylated. Dephosphorylated by PTPN11.
  • Function
  • Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.

Recommended Products

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CDC73"

Fab Fragment Antibody

CAT Product Name Application Type
DrMAB-281 Human Anti-CDC73 Recombinant Antibody (clone D257); Fab Fragment IP, IF, ELISA, IP-MS Human Fab

Recombinant Antibody

CAT Product Name Application Type
DrMAB-283 Human Anti-CDC73 Recombinant Antibody (clone D259) IF, ELISA, IP-MS Human IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0609 Hi-Affi™ Rabbit Anti-CDC73 Recombinant Antibody (clone DS609AB) WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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