Mouse Anti-CDX2 Recombinant Antibody (clone 8D9)
CAT#: VS3-WK1612
This antibody is a mouse recombinant antibody against human CDX2, which is a major regulator of intestine-specific genes involved in cell growth an differentiation. The clone 8D9 can be used in WB analysis at a dilution of 1/1000-1/2000 and IHC analysis at a dilution of 1/50-1/200.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45669/if_selected.jpg
Normal Tissue
Figure 2 Duodenum
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Paneth cells
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_9_2.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2221/5840_A_8_3.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (CACO-2, CAPAN-2, HEK93)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165556-CDX2
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Specifications
- Immunogen
- Synthesized peptide derived from human CDX-2
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CDX2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 8D9
- Applications
- IHC-P, WB
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC-P: 1/50-1/200
WB: 1/1000-1/2000
Target
- Alternative Names
- Caudal Type Homeobox 2; Caudal-Type Homeobox Protein 2; CDX-3; CDX3; Caudal Type Homeo Box Transcription Factor 2; Caudal Type Homeobox Transcription Factor 2; Homeobox Protein MiniCDX2; Homeobox Protein CDX-2; CDX2/AS
- Gene ID
- 1045
- UniProt ID
- Q99626
- Long Name
- Caudal Type Homeobox 2
- Sequence Similarities
- Belongs to the Caudal homeobox family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
- Protein Refseq
- NP_001256.3
- Function
- Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity).
Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
Isotype Control
- CAT
- Product Name
See other products for "CDX2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0646 | Hi-Affi™ Rabbit Anti-CDX2 Recombinant Antibody (clone DS646AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0141J | Mouse Anti-CDX2 Recombinant Antibody (ZG-0141J) | IHC-P, IF | Mouse IgG |
| ZG-0142J | Mouse Anti-CDX2 Recombinant Antibody (ZG-0142J) | IHC-P, IF | Mouse IgG |
| ZG-0143J | Mouse Anti-CDX2 Recombinant Antibody (clone 14H6) | WB, IF, ICC, IHC-P | Mouse IgG |
| VS3-XY488 | Mouse Anti-CDX2 Recombinant Antibody (clone 3G9B9) | ELISA, WB, FC | Mouse IgG1 |
| VS3-XY489 | Mouse Anti-CDX2 Recombinant Antibody (clone 2F12A6) | ELISA, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY61 | AbPlus™ Anti-CDX2 Magnetic Beads (4B9-B12-E9) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY418 | Anti-CDX2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1352 | Anti-Mouse CDX2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1351 | Anti-Human CDX2 Immunohistochemistry Kit | IHC |
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