Rabbit Anti-CES1 Recombinant Antibody (clone R05-5K4) (CAT#: VS3-XY3312)
This antibody is a recombinant rabbit antibody against CES1 (Carboxylesterase 1), which involves in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. It specifically reacts with human, mouse and rat CES1. It has been reported for use in Western Blot, Immunoprecipitation and Flow cytometry. The recommended dilutions of Western Blot, Immunoprecipitation and Flow cytometry is 1/500-1/1000, 1/20 and 1/50-1/100, respectively.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46717/753_F6_2_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46717/753_F6_2_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_B_7_5.jpg
Figure 3 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_A_8_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_A_7_4.jpg
Figure 5 Gallbladder
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_A_5_4.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12023/155105_A_5_4.jpg
Figure 6 RNA cell line category: Group enriched (Hep G2, THP-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198848-CES1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198848-CES1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CES1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-5K4
- Applications
- WB, IP, FC
- Related Disease
- Egasyn
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1
- Gene ID
- 1066
- UniProt ID
- P23141
- Long Name
- Carboxylesterase 1
- Cellular Localization
- Endoplasmic reticulum lumen, Cytoplasm, Lipid droplet
- Post Translation Modifications
- Contains sialic acid. (P23141-EST1_HUMAN)
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19. (P23141-EST1_HUMAN)
Glycosylation at Asn79 (NX_P23141 [NX_P23141-1])
Modification sites at PhosphoSitePlus (P23141)
Glycosylation from GlyConnect EST1_HUMAN (1462)
Glycosylation from GlyGen (P23141) 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005255831.1; XP_054185552.1
- Function
- Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester.
Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine.
Catalyzes the transesterification of cocaine to form cocaethylene.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2018z | Mouse Anti-CES1 Recombinant Antibody (clone 16F7) | WB, ELISA, IF, IHC | Mouse IgG1 |
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