Recombinant Anti-CGB3 Eliminating Antibody, pH-Sensitive (AB4 var.)
CAT#: VS-0625-YC63
The anti-CGB3 eliminating antibody is an engineered pH-sensitive antibody against human CGB3. CGB3, part of the glycoprotein hormone beta chain family, important for pregnancy maintenance. The antibody has a novel CGB3-sweeping activity in vivo, which selectively eliminatesthe soluble CGB3 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 High expression in placenta.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42/1696_A_2_7_val_selected.jpg
Normal Tissue
Figure 2 Low expression in prostate.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42/1696_A_3_5_val_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38925/537_C10_3_selected.jpg
Normal Tissue
Figure 4 Placenta
Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38934/101364_A_2_7.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (BEWO)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104827-CGB3
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Specifications
- Immunogen
- Recombinant human chorionic gonadotropin
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human CGB3
- Species Reactivity
- Human
- Clone
- AB4 var.
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0123MZ | Chicken Anti-Chorionic Gonadotropin β Subunit (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0678 | Hi-Affi™ Rabbit Anti-CGB3 Recombinant Antibody (clone DS678AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-036CN | Human Anti-CGB3 Recombinant Antibody (clone YC020) | ELISA | Chimeric (mouse/human) IgG |
| NS-036CN-F(E) | Human Anti-CGB3 Recombinant Antibody (clone YC018); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
| NS-036CN-S(P) | Mouse Anti-CGB3 Recombinant Antibody (clone YC019); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1674-FY | Human Anti-CGB3 Recombinant Antibody (clone B11) | ELISA, FC | Human IgG |
| FAMAB-1328CQ | Human Anti-CGB3 Recombinant Antibody (clone 3A2) | ELISA | Human IgG1 |
| VS3-FY374 | Recombinant Mouse Anti-CGB3 Antibody (clone 4F4-2D8-1F7) | IHC-P | Mouse IgG |
| VS3-WK1624 | Recombinant Mouse Anti-CGB3 Capture Antibody (clone 1E7) | ELISA | Mouse IgG1 |
| VS3-WK1625 | Recombinant Mouse Anti-CGB3 Detection Antibody (clone 15B3) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1674-FY-F(E) | Human Anti-CGB3 Recombinant Antibody (clone B11); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1674-FY-S(P) | Human Anti-CGB3 Recombinant Antibody (clone B11); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1410 | Anti-CGB3 Immunohistochemistry Kit | IHC |
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