Mouse Anti-CLDN1 Recombinant Antibody (clone PT0509)
CAT#: VS3-CJ195
This product is a mouse antibody that recognizes CLDN1.
Gene Expression
Normal Tissue
Figure 1 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_4.jpg
Normal Tissue
Figure 2 Kidney
Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_5_6.jpg
Normal Tissue
Figure 4 Skin
Cells in granular layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Hair follicles
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_B_9_1.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (EFO-21, HaCaT, hTCEpi, RPTEC TERT1, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163347-CLDN1
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Specifications
- Immunogen
- Synthesized peptide derived from human Claudin 1
- Host Species
- Mouse
- Specificity
- Human CLDN1
- Species Reactivity
- Human
- Clone
- PT0509
- Applications
- IHC-P, WB
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- CLD1; SEMP1; ILVASC
- Gene ID
- 9076
- UniProt ID
- O95832
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, Cell membrane Membrane, Tight junction
- Protein Refseq
- NP_066924.1
- Function
- Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
(Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010, PubMed:24038151).
Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010).
Acts as a receptor for dengue virus (PubMed:24074594).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "CLDN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-594-VHH | Recombinant Anti-Human CLDN1 VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2083z | Mouse Anti-CLDN1 Recombinant Antibody (clone 1B9) | WB, ELISA, IHC | Mouse IgG2a, κ |
| HPAB-0080-LS | Mouse Anti-CLDN1 Recombinant Antibody (HPAB-0080-LS) | WB, FC, IF, IP, Inhib | Mouse IgG |
| HPAB-M0488-YC | Rat Anti-CLDN1 Recombinant Antibody (HPAB-M0488-YC) | FC, Inhib, FuncS | Rat IgG2b, κ |
| HPAB-M0489-YC | Human Anti-CLDN1 Recombinant Antibody (HPAB-M0489-YC) | FC, Inhib, FuncS | Humanized IgG |
| VS3-XY3317 | Rabbit Anti-CLDN1 Recombinant Antibody (clone R09-5K9) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-484LC | Mouse Anti-CLDN1 Recombinant Antibody (TAB-484LC) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0716 | Hi-Affi™ Rabbit Anti-CLDN1 Recombinant Antibody (clone DS716AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-LS-S(P) | Mouse Anti-CLDN1 Recombinant Antibody; scFv Fragment (HPAB-0080-LS-S(P)) | WB, FC, IF, IP, Inhib | Mouse scFv |
| HPAB-M0488-YC-S(P) | Rat Anti-CLDN1 Recombinant Antibody; scFv Fragment (HPAB-M0488-YC-S(P)) | FC, Inhib, FuncS | Rat scFv |
| HPAB-M0489-YC-S(P) | Human Anti-CLDN1 Recombinant Antibody; scFv Fragment (HPAB-M0489-YC-S(P)) | FC, Inhib, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-LS-F(E) | Mouse Anti-CLDN1 Recombinant Antibody; Fab Fragment (HPAB-0080-LS-F(E)) | WB, FC, IF, IP, Inhib | Mouse Fab |
| HPAB-M0488-YC-F(E) | Rat Anti-CLDN1 Recombinant Antibody; Fab Fragment (HPAB-M0488-YC-F(E)) | FC, Inhib, FuncS | Rat Fab |
| HPAB-M0489-YC-F(E) | Human Anti-CLDN1 Recombinant Antibody; Fab Fragment (HPAB-M0489-YC-F(E)) | FC, Inhib, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY66 | AbPlus™ Anti-CLDN1 Magnetic Beads (VS-0424-XY66) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC137 | Recombinant Anti-CLDN1 Vesicular Antibody, EV Displayed (VS-0425-YC137) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1480 | Anti-CLDN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1481 | Anti-Mouse CLDN1 Immunohistochemistry Kit | IHC |
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