Mouse Anti-CLDN1 Recombinant Antibody (clone PT0509) (CAT#: VS3-CJ195)

• Immunogen
• Synthesized peptide derived from human Claudin 1

• Host Species
• Mouse

• Specificity
• Human CLDN1

• Species Reactivity
• Human

• Clone
• PT0509

• Applications
• IHC-P, WB

• Conjugate
• Unconjugated

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 0.5% BSA, PBS.

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• CLD1; SEMP1; ILVASC

• Gene ID
• 9076

• UniProt ID
• O95832

• Sequence Similarities
• Belongs to the claudin family.

• Cellular Localization
• Cell junction, Cell membrane Membrane, Tight junction

• Protein Refseq
• NP_066924.1

• Function
• Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
  (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010, PubMed:24038151).
  Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010).
  Acts as a receptor for dengue virus (PubMed:24074594).

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Select a product category from the dropdown menu below to view related products.