Rabbit Anti-CLDN1 Recombinant Antibody (clone R09-5K9) (CAT#: VS3-XY3317)
The product is a recombinant rabbit antibody against CLDN1 (Claudin 1), which acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. CLDN1 associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. It specifically reacts with human, mouse and rat CLDN1. It has been reported for use in Western Blot.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_4.jpg
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_4.jpg
Figure 2 Kidney
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_5.jpg
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_5.jpg
Figure 3 Testis
(Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_5_6.jpg
(Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_5_6.jpg
Figure 4 Skin
(Cells in granular layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Hair follicles
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_B_9_1.jpg
(Cells in granular layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Hair follicles
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_B_9_1.jpg
Figure 5 RNA cell line category: Group enriched (EFO-21, HaCaT, hTCEpi, RPTEC TERT1, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163347-CLDN1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163347-CLDN1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CLDN1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-5K9
- Applications
- WB
- Related Disease
- Sclerosing Cholangitis
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- CLD1; SEMP1; ILVASC
- Gene ID
- 9076
- UniProt ID
- O95832
- Long Name
- Claudin 1
- Cellular Localization
- Cell junction, Cell membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (O95832)
Modification sites at neXtProt (NX_O95832)
Glycosylation from GlyGen (O95832) 4 sites
- Protein Refseq
- NP_066924.1
- Function
- Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-594-VHH | Recombinant Anti-Human CLDN1 VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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