Rabbit Anti-DNTT Recombinant Antibody (clone R08-8D9) (CAT#: VS3-FY1898)

• Immunogen
• Synthetic peptide of human TdT

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse DNTT

• Species Reactivity
• Human, Mouse

• Clone
• R08-8D9

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 59 kDa, while the observed molecular weight stands at 59 kDa.

• Related Disease
• Lymphoblastic Lymphoma and Myeloid Sarcoma

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• DNA Nucleotidylexotransferase; Terminal Deoxynucleotidyltransferase; Terminal Addition Enzyme; Terminal Transferase; EC 2.7.7.31; TDT

• Gene ID
• 1791

• UniProt ID
• P04053

• Sequence Similarities
• Belongs to the DNA polymerase type-X family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Ubiquitination at Lys59, Lys199, Lys209, Lys222, Lys250, Lys261, Lys290, Lys339, Lys371, Lys386, Lys393, Lys408, Lys425, and Lys468 (NX_P04053 [NX_P04053-1])
  Modification sites at PhosphoSitePlus (P04053)
  Glycosylation from GlyGen (P04053) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001017520.1; NP_004079.3

• Function
• Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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