AbPlus™ Anti-DUSP3 Magnetic Beads (VS-0724-YC517) (CAT#: VS-0724-YC517)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-DUSP3 specific antibody

• Target
• DUSP3

• Immunogen
• Recombinant human DUSP3/VHR, aa 1-185.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

• Alternative Names
• Dual Specificity Phosphatase 3; Dual Specificity Protein Phosphatase VHR; Vaccinia Virus Phosphatase VH1-Related; Vaccinia H1-Related Phosphatase; VHR; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 3; EC 3.1.3.16; EC 3.1.3.48;

• Gene ID
• 1845

• UniProt ID
• P51452

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