Mouse Anti-ECT2 Recombinant Antibody (VS3-FY2694) (CAT#: VS3-FY2694)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Epithelial cell transforming 2 of human and mouse origins

• Species Reactivity
• Human, Mouse

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 103.5 kDa.

• Related Disease
• Cataract 36 and Squamous Cell Carcinoma

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Epithelial Cell Transforming 2; Epithelial Cell-Transforming Sequence 2 Oncogene; Epithelial Cell Transforming Sequence 2 Oncogene; Protein ECT2; ARHGEF31

• Gene ID
• 1894

• UniProt ID
• Q9H8V3

• Cellular Localization
• Nucleus
  Cytoplasm
  Cytoplasm, cytoskeleton, spindle
  Cleavage furrow
  Midbody
  Cell junction
  Cell junction, tight junction
  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

• Post Translation Modifications
• Phosphorylated by PLK1 in vitro.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt
  Glycosylation from GlyGen 2 sites, 1 O-linked glycan (2 sites)

• Function
• Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression.
  Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner.
  Plays a role in the regulation of neurite outgrowth.
  Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation.
  Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

Select a product category from the dropdown menu below to view related products.