AibGenesis™ Rabbit Anti-EIF3B Recombinant Antibody (AibG-Rb-EI391)
CAT#: VS-0426-FY391
Established via our AI-powered antibody discovery platform, this Rabbit IgG targets EIF3B. Validated for WB, FC, and IP across multiple species, it offers high specificity for researchers investigating the eIF3 scaffolding complex and its essential role in the assembly of the 43S pre-initiation complex.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17562/962_H3_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_A_8_8.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_A_7_4.jpg
Normal Tissue
Figure 6 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_A_2_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48983/124400_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106263-EIF3B
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human EIF3B
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-EI391
- Applications
- Western Blot, Immunocytochemistry, Flow Cytometry, Immunoprecipitation
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Craniotubular Dysplasia, Ikegawa Type and Mouth Disease
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, 0.05% Protective protein, 50% Glycerol
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:2000), Immunocytochemistry (1:50-1:200), Flow Cytometry (1:20-1:100), Immunoprecipitation (1:20-1:50)
Target
- Alternative Names
- eIF3b; EIF3S9; hPrt1; PRT1; eIF3B
- UniProt ID
- P55884
- Long Name
- Eukaryotic Translation Initiation Factor 3 Subunit B
- Sequence Similarities
- Belongs to the eIF-3 subunit B family.
- Cellular Localization
- Cytoplasm, Cytoplasm, Stress granule
- Post Translation Modifications
- Phosphorylated.
Phosphorylation is enhanced upon serum stimulation.
Ubiquitination at Lys209, Lys230, Lys257, Lys288, Lys324, Lys345, Lys364, Lys516, Lys535, Lys552, Lys604, Lys718, Lys729, Lys744, and Lys762 (NX_P55884 [NX_P55884-1])
Modification sites at PhosphoSitePlus (P55884)
Glycosylation from GlyGen (P55884) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011513901.1; XP_016868242.1; XP_047276956.1; XP_047276957.1; XP_054215256.1
- Function
- RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, 17581632, 25849773, 27462815).
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "EIF3B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1123 | Hi-Affi™ Rabbit Anti-EIF3B Recombinant Antibody (clone DS1123AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY484 | Recombinant Rabbit Anti-EIF3B Antibody (clone R09-4I5) | WB, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC515 | AbPlus™ Anti-EIF3B Magnetic Beads (VS-0724-YC515) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2218 | Anti-EIF3B Immunohistochemistry Kit | IHC |
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