Mouse Anti-P. falciparum CSP Recombinant Antibody (clone 850) (CAT#: VS-0724-FY25)
This is a mouse antibody that specifically recognizes PfCSP. The clone 850 binds to NANP repeats with high affinity and achieves potent parasite inhibition. The clone 850 is one of the highest affinity NANP binders described to date, with KD of 1 nM, 25 pM, and 32 pM for NPNA3 and NANP6 peptides and recombinant full-length PfCSP, respectively. The clone 850 was isolated following immunization with an antigen containing PfCSP repeats in a transgenic mouse model.
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Inhib
Figure 1. Recombinant MOUSE Anti-CSP Antibody (B5) in Inhibition.
Parasite inhibition and binding of mAb 850. Capacity of mAb 850 to inhibit the hepatocyte traversal activity of Pf sporozoites in vitro.
1. Kucharska, Iga, et al. "High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire." PLoS pathogens 18.11 (2022): e1010999. 2. under Open Access license cc BY 4.0. without modification.
Specifications
- Immunogen
- A PfCSP repeat-containing antigen in a transgenic mouse model.
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG
- Specificity
- P. falciparum CSP
- Species Reactivity
- P. falciparum strain 3D7
- Clone
- 850
- Applications
- Inhibition
- Related Disease
- Malaria
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Inhibition: 0.5 μg/mL
Target
- Alternative Names
- P. falciparum CSP; CSP
- UniProt ID
- Q7K740
- Long Name
- P. falciparum CSP
- Sequence Similarities
- Belongs to the plasmodium circumsporozoite protein family.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane
- Post Translation Modifications
- During host cell invasion, proteolytically cleaved at the cell membrane in the region I by a papain-like cysteine protease of parasite origin (By similarity).
Cleavage is triggered by the sporozoite contact with highly sulfated heparan sulfate proteoglycans (HSPGs) present on the host hepatocyte cell surface.
- Protein Refseq
- XP_001351122.1
- Function
- CSP, or Content Security Policy, is a security standard that helps prevent the exploitation of cross-site scripting (XSS) attacks by allowing website owners to define where resources like JavaScript can be loaded from. CSP works by specifying the domains from which resources can be loaded, thereby minimizing the risk of XSS attacks by restricting the sources of executable scripts on a website.
The primary function of CSP is to enhance the security of web applications by reducing the potential vulnerabilities that can be exploited by malicious actors. By implementing CSP, website owners can control which external resources can be loaded, reducing the risk of unauthorized code execution and protecting user data.
Recommended Products
Isotype Control
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Epitope-Specific Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0903CQ | Recombinant Mouse Anti-P. falciparum CSP Antibody (A24) | ELISA, IHC | IgG |
| EPAF-0906CQ | Recombinant Mouse Anti-P. falciparum CSP Antibody (3D6) | Inhib | IgG |
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