Mouse Anti-ER Recombinant Antibody (clone JS34/32) (CAT#: FAMAB-0100YC)
The anti-Estrogen receptor antibody JS34/32 interacts with different forms of calf receptor as well as with rat and human receptors. JS34/32 are able to form only a 1:l complex with the 8s form of the receptor, whereas a 2:l receptor-IgG complex is formed at low antibody concentration with the high-salt or nuclear form of receptor. The antibodies JS34/32 and JS28/32 prevent neither the nuclear uptake of the receptor nor the extraction of the translocated receptor from the nuclei.
Specific Inquiry
Figure 1 Scatchard analysis of receptor-monoclonal antibodies interaction.
The equilibrium dissociation constant of the estrogen receptor-antibody complex was determined for antibodies from the clone JS34/32 in solid phase as well as in solution.
Moncharmont, B., Su, J., & Parikh, I. (1982). Monoclonal antibodies against estrogen receptor: interaction with different molecular forms and functions of the receptor. Biochemistry, 21(26), 6916-6921.
Specifications
- Immunogen
- Purified preparation of estrogen receptor from calf uterus
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Bovine ER
- Species Reactivity
- Rat, Human, Bovine
- Clone
- JS34/32
- Applications
- IP
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Estrogen receptor; ER
Related Resources
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0100-YC-S(P) | Mouse Anti-ER Recombinant Antibody (clone JS34/32); scFv Fragment | IP | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0100-YC-F(E) | Mouse Anti-ER Recombinant Antibody (clone JS34/32); Fab Fragment | IP | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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