Recombinant Anti-F11 Biparatopic Antibody, Symmetric tandem sdAb (CAT#: VS-0525-YC15)

• Host Animal 1
• Llama

• Host Animal 2
• Llama

• Specificity
• Factor XI

• Species Reactivity
• Human, Cynomolgus, Rabbit

• Type
• Symmetric tandem sdAb

• Valency
• 2 + 2

• Affinity Constant
• 0.674 nM (Human FXI)
  0.152 pM (Cyno FXI)
  0.183 nM (Rabbit FXI)

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, Inhib

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Coagulation Factor XI

• Introduction
• This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria.

• Alternative Names
• FXI; PTA; Cf11; 1600027G01Rik

• Gene ID
• 109821

• UniProt ID
• Q91Y47

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