Anti-FANCM Antibody Prodrug, Protease Activated (CV5.1)
CAT#: VS-1025-YC146
The Anti-FANCM Antibody Prodrug, Protease Activated (CV5.1) is an antibody prodrug comprised of a recombinant mouse antibody targeting human FANCM, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FANCM protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FANCM effectively. FANCM is a critical component of the Fanconi Anemia (FA) pathway, which is essential for DNA interstrand cross-link repair. Mutations in FANCM are associated with increased risk for various cancers, classifying it as a tumor suppressor gene that, when defective, causes genomic instability.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55144/883_B2_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187790-FANCM
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FANCM
- Target
- FANCM
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- CV5.1
- Epitope
- AA 1507-1679
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 KDa; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250
- Gene ID
- 57697
- UniProt ID
- Q8IYD8
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1133CQ | Mouse Anti-FANCM Recombinant Antibody (clone CV5.1) | IF, WB, FC | Mouse IgG1 |
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