Rabbit Anti-FBXW7 Recombinant Antibody (VS13-YC384)
CAT#: VS13-YC384
The Rabbit Anti-FBXW7 Recombinant Antibody is specific for human FBXW7. FBXW7, an F-box protein, directs cyclin E for degradation, with mutations implicated in cancer pathogenesis, particularly ovarian and breast cancer, through regulatory pathways affecting cell cycle proteins. The anti-FBXW7 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13793/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29987/159891_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29987/159891_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29987/159891_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29987/159891_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29987/159891_A_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29987/159891_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000109670-FBXW7
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Specifications
- Immunogen
- Recombinant human Fbxw7.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FBXW7
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- F-Box And WD Repeat Domain Containing 7; F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase; F-Box And WD-40 Domain Protein 7; F-Box Protein FBX30; SEL-10; Fbx30; SEL10; HCdc4; FBW7; HAgo; F-Box And WD-40 Domain-Containing Protein 7; F-Box/WD Repeat-Containing Protein 7;
- Gene ID
- 55294
- UniProt ID
- Q969H0
- Long Name
- F-Box And WD Repeat Domain Containing 7
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FBXW7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4016z | Mouse Anti-FBXW7 Recombinant Antibody (clone 19H10) | WB, ELISA, IHC | Mouse IgG2a, κ |
| MOB-2472MZ | Recombinant Mouse Anti-Human FBXW7 Antibody (clone 3D1) | IHC-P, WB | Mouse antibody |
| MRO-1858-CN | Rabbit Anti-FBXW7 Polyclonal Antibody (MRO-1858-CN) | WB, IF, FC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1266 | Hi-Affi™ Rabbit Anti-Fbxw7 Recombinant Antibody (clone DS1266AB) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY824 | Anti-FBXW7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2473 | Anti-Mouse FBXW7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2472 | Anti-Human FBXW7 Immunohistochemistry Kit | IHC |
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