Anti-FSTL3 Antibody Prodrug, Protease Activated (VS-1025-YC165)
CAT#: VS-1025-YC165
The Anti-FSTL3 Antibody Prodrug, Protease Activated (VS-1025-YC165) is an antibody prodrug comprised of a recombinant mouse antibody targeting human FSTL3, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FSTL3 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FSTL3 effectively. FSTL3 is crucial for the establishment and maintenance of pregnancy. It also plays a role in the regulation of the ovarian cycle and testicular function. It has been studied as a potential biomarker in various cancers, including lung and ovarian cancer. It can be associated with prognosis and progression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45378/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows distinct nuclear and cytoplasmic positivity in neuronal cells and glial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_A_9_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_A_8_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_A_6_6.jpg
Normal Tissue
Figure 9 Placenta
Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24899/56136_A_3_7.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (BEWO, hTCEpi, SiHa, U-2197)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070404-FSTL3
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FSTL3
- Target
- FSTL3
- Species Reactivity
- Human, Mouse (Weakly)
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
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Datasheet
MSDS
COA
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| MOR-4334 | Hi-Affi™ Rabbit Anti-Fstl3 Recombinant Antibody (clone SI423DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| HPAB-N0094-YC | Mouse Anti-FSTL3 Recombinant Antibody (HPAB-N0094-YC) | Neut, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
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| HPAB-N0095-YC | Mouse Anti-FSTL3 Recombinant Antibody (HPAB-N0095-YC) | Neut, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
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| HPAB-N0094-YC-S(P) | Mouse Anti-FSTL3 Recombinant Antibody; scFv Fragment (HPAB-N0094-YC-S(P)) | Neut, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-N0095-YC-S(P) | Mouse Anti-FSTL3 Recombinant Antibody; scFv Fragment (HPAB-N0095-YC-S(P)) | Neut, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-N0094-YC-F(E) | Mouse Anti-FSTL3 Recombinant Antibody; Fab Fragment (HPAB-N0094-YC-F(E)) | Neut, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0095-YC-F(E) | Mouse Anti-FSTL3 Recombinant Antibody; Fab Fragment (HPAB-N0095-YC-F(E)) | Neut, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
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